Tissue-mimicking materials (TMMs) are widely used in quality assurance (QA) phantoms to assess the performance of ultrasound scanners. The International Electrotechnical Commission (IEC) defines the acoustic parameters of up to 10 MHz. To manufacture a …

Happy Holidays from FUJIFILM VisualSonics SPECIAL HOLIDAY MESSAGE: Reflecting back on 2016 and Looking ahead to 2017 As 2016 winds down and we look towards upcoming holiday celebrations with family and friends, we at FUJIFILM VisualSonics take this moment …

Introduction: Wound healing after myocardial infarction (MI) is mediated by different cell types, secreted proteins, components of the extracellular matrix (ECM) and, as increasing evidences suggest, extracellular vesicles (EVs). We aim to determine the …

Background: In the heart, slow delayed rectifier channels provide outward currents (IKs) for action potential (AP) repolarization in a region- and context-dependent manner. In diseased hearts, chronic elevation of angiotensin II (Ang II) may remodel IKs …

In efforts to improve solid tumor imaging, and enable image-guided drug delivery (IGDD), multiple types of clinical imaging modalities have been combined with nanoparticle platforms1,2. These have improved ability to understand tumor microenvironment and …

Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of melatonin on cardiomyocyte mitophagy in mice with DCM and elucidated their underlying mechanisms. …

Heart failure is associated with low cardiac output (CO) and low brain perfusion that imposes a significant risk for accelerated brain aging and Alzheimer disease development. Although clinical heart failure can emerge several years following acute …

Metastasis is the leading cause of cancer-related deaths. A number of chemotherapeutic and early diagnosis strategies, including nanomedicine, have been developed to target metastatic tumor cells. However, simultaneous inhibition and imaging of metastasis …

Tendinopathy includes cases with chronic tendon pain and spontaneous tendon ruptures, which is putatively resulted from failed tendon healing. Overuse is a major risk factor of tendinopathy, which can impose mechanical and oxidative stress to tendons. …

Background: The spleen plays an important role in erythrocyte turnover, adaptive immunity, antibody production, and the mobilization of monocytes/macrophages (Mφ) following tissue injury. In response to trauma, the spleen initiates production of …