Background-—Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological …

Patients with heart failure (HF) have a high prevalence of depression associated with a worse prognosis, particularly in older women. This study evaluated whether sex and estrogens affect depression-like behavior and associated neuroinflammation induced …

Cardiovascular complications are common after TBI and are associated with increased morbidity and mortality. In this study, we investigated the possible role of the immune system in mediating cardiac dysfunction post-TBI in mice. Adult male C57BL/6J mice …

Autologous veins are the most widely used grafts for bypassing small arteries in coronary and peripheral arterial occlusive diseases. However, they have limited availability and cause donor- site morbidity. Here, we report a direct comparison of acellular …

OBJECTIVE: This study aims to ex- plore the role and the mechanism of Parkin pro- tein in cardiac function and ventricular remodel- ing in myocardial infarction (MI) rats, and to pro- vide a new sight for the treatment of myocardi- al infarction. …

There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on evaluating vascular responses and putative therapies in experimental AVFs. We studied an AVF in mice …

Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted and excitation-contraction …

OBJECTIVE: To investigate the effect of aquaporin-1 (AQP1) on heart edema in- duced by transverse aortic constriction (TAC) in mice, and to explore whether inhibiting the ex- pression of AQP1 could attenuate myocardial edema and improve cardiac function. …

Photoacoustic (PA) computed tomography (PACT) benefits from genetically encoded probes with photochromic behavior, which dramatically increase detection sensitivity and specificity through photoswitching and differential imaging. Starting with a DrBphP …

Background: Advanced-stage neuroblastoma patients require multiagent chemotherapy. Intratumoral implantation of vincristine-loaded silk gel uses local diffusion to decrease orthotopic neuroblastoma tumor growth in mice. We hypothesize that injecting …