MSK
See changes in tissue and vascular structure in 2D & 3D
Ultrasound for In Vivo Assessment of Rheumatoid Arthritis
How much inflammation is in the arthritic joints? Assess the musculoskeletal system with Vevo technology!
Rapid, completely non-invasive visualization of the arthritic joint.
Using ultra-high frequency ultrasound and photoacoustics, visualize changes in tissue and vascular structure in 2D and 3D with resolution down to 30 microns, in vivo. Tissue oxygenation, capillary function, tissue inflammation, bone erosion and more can be assessed longitudinally without interfering with your experiment.
- Detect early onset of arthritis in drug-induced or spontaneous mouse models
- Assess levels of inflammation
- 3D reconstruction of joints
- Perform image guided injections (e.g. into the knee)
- Detect hemoglobin and oxygenation levels with the Vevo LAZR photoacoustic platform
MSK Applications
3D Power Doppler
3D power Doppler image of a swollen joint due to collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria.
Vascular Imaging
3D image illustrating the vascularity in the mouse paw in a model of collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria.
Photoacoustic Imaging
Multiplexed photoacoustic image of the mouse hindlimb after ICG injection (isolated in the popliteal lymph node).
Oxy-Hemo Mode
3D rendered image of oxygen saturation in the mouse ear, imaged with photoacoustics in Oxy-Hemo Mode.
Use Vevo Ultrasound to Image:
• Collagen induced arthritis (CIA)
• TNFa overexpressing animals
• Musculoskeletal (MSK) disease
Gallery
Canine eye in vivo
Entire canine eye visualized in vivo with the Vevo F2, scanned using a UHF22x transducer.
Canine eye angle of the anterior chamber
Canine eye imaged in vivo on the Vevo F2 scanned using the UHF71x.
Canine eye, Ciliary body and processes
In vivo canine eye with ciliary processes, imaged with high-frequency on the Vevo F2 scanned using the UHF71x.
Porcine eye, Ciliary body and processes
Porcine eye imaged ex-vivo using the Vevo F2 with a UHF71x transducer.
Mouse Eye in 3D
Mouse eye scanned using the UHF71x transducer using the Vevo F2 in 3D.
Imaging of lymphatics in the mouse.
High-resolution ultrasound (greyscale) and photoacoustic (red, blue and green) image of the mouse hindlimb showing Evan's Blue (blue) and ICG (green) dye in the lymphatic vessels and the popliteal lymph node.
Publications
TOP PAPER
In vivo imaging in experimental spinal cord injury – Techniques and trends
Brain and Spine
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TOP PAPER
Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity
Journal of Orthopaedic Research
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TOP PAPER
Clinically-applicable perfluorocarbon-loaded nanoparticles for in vivo photoacoustic,19f magnetic resonance and fluorescent imaging
Nanotheranostics
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TOP PAPER
Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents
Molecular Pharmaceutics
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TOP PAPER
Accuracy of Ultrasound-Guided versus Landmark-Guided Intra-articular Injection for Rat Knee Joints
Ultrasound in Medicine & Biology
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TOP PAPER
Ultrasound as a New Imaging Tool to Assess Pathological Change of Joints in Preclinical Mouse Models of Osteoarthritis
Journal of Orthopaedics and Physiotherapy
, Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice
Journal of Translational Medicine
, Direct optogenetic activation of upper airway muscles in an acute model of upper airway hypotonia mimicking sleep onset
SLEEP
, Anti-inflammatory therapy enables robot-actuated regeneration of aged muscle
Science robotics
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