Study Tissue Ischemia and Blood Reperfusion in Real Time
Obtain real-time dynamic measurements of oxygen saturation and vascular reperfusion in your disease model.
Tissue ischemia, as well as blood reperfusion in ischemic organs, can be investigated in vivo and in real-time with the Vevo F2 LAZR-X photoacoustic system.
The physiological and biochemical changes induced in the affected tissue or organ hold important clinical relevance in studies of disease and development of therapeutics.
Features include:
- Anatomy-specific oxygen saturation and total hemoglobin measurement
- Detection and quantification of biomarkers (eg. VEGFR2, VCAM)
- Assessing angiogenesis progression
- Quantifying perfusion kinetics
- Blood flow measurements
Example Study: Acute ischemia induced in mouse hindlimb with a tourniquet showing oxygen saturation during ischemia and post-reperfusion



Use a Vevo System for:
- Femoral Artery Ligation models
- Peripheral Artery Disease assessment
- Ischemic Bowel Disease (Ischaemic Colitis)
- Myocardial infarct
- Stroke studies
- Wound healing and tissue injury
Gallery
Publications
Dental Pulp Mesenchymal Stem Cells Attenuate Limb Ischemia via Promoting Capillary Proliferation and Collateral Development in a Preclinical Model
Stem Cells International
, Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia
Cell Death and Disease
, Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain
Frontiers in Cardiovascular Medicine
, Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury
Neurobiology of Disease
, Evaluation of Hemodynamics in a Murine Hindlimb Ischemia Model Using Spatial Frequency Domain Imaging
Lasers in Surgery and Medicine
, Short-term molecular and cellular effects of ischemia/reperfusion on vascularized lymph node flaps in rats
PLoS ONE
, Mitochondrial transplantation ameliorates acute limb ischemia
Journal of Vascular Surgery
, Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy
American Journal of Transplantation
, Mechanism of angiogenesis promotion with Shexiang Baoxin Pills by regulating function and signaling pathway of endothelial cells through macrophages
Atherosclerosis
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