Background: Heart failure with preserved ejection fraction (HFpEF) is associated with endothelial dysfunction, but the molecular mechanisms still remain unclear. Whether exercise training (ET) along with which optimal modality can improve endothelial …

Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis‐ associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, …

SGLT2 inhibitors have profound benefits on reducing heart failure and cardiovascular mortality in individuals with type 2 diabetes, although the mechanism(s) of this benefit remain poorly understood. Because changes in cardiac bioenergetics play a …

Aims: Cardiac hypertrophy is characterized by a shift in metabolic substrate utilization, but the molecular events underly- ing the metabolic remodelling remain poorly understood. We explored metabolic remodelling and mitochondrial dysfunction in cardiac …

Blood glucose lowering therapies can positively or negatively affect heart function in Type 2 diabetes, or they can have neutral effects. Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose by preventing the proteolytic inactivation of …

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Cardiac two pore domain potassium channels (K2P) exist in organisms from Drosophila to humans, however their role in cardiac function is not known. We identified a K2P gene, CG8713 (sandman), in a Drosophila genetic screen and show that sandman is …

An early manifestation of coronary artery disease in advanced age is the development of microvascular dysfunction leading to deficits in diastolic function. Our lab has previously shown that epicardial treatment with adipose-derived stromal vascular …

Heart failure remains a major cause of morbidity and mortality in developed countries. There is still a strong need to devise new mechanism-based treatments for heart failure. Numerous studies have sug- gested the importance of the Ca2þ-dependent protease …

Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients.However, the molecular and cellu- lar mechanism of this provocative adverse effect is unclear. …