c-Jun dimerization protein 2 (JDP2) deficiency promotes cardiac hypertrophy and dysfunction in response to pressure overload …

Cross section of the mouse abdomen highlighting major structures, including liver metastasis. … … Liver Metastasis …

Multimodal imaging guided synergistic therapy promises more accurate diagnosis and higher therapeutic efficiency than single imaging modality or their simple "mechanical" combination. In this research, we fabricated a new multifunctional drug delivery …

Epithelial ovarian carcinoma (EOC) is the most prevalent form of ovarian cancer in the United States, representing approximately 85% of all cases and causing more deaths than any other gynecologic malignancy. We propose that optimized control of EOC …

Although pathologic hypertrophic hearts currently maintain output, sustained cardiac hypertrophy could predispose a patient to arrhythmia and sudden death, and also cause heart failure. Thus, finding effective treatment and exploring the underlying …

Cardiac hypertrophy, as a response to hemodynamic stress, is associated with cardiac dysfunction and death, but whether hypertrophy itself represents a pathological process remains unclear. Hypertrophy is driven by changes in myocardial gene expression …

Beta-adrenergic stimulation of the heart increases ICa. PKA dependent phosphorylation of several amino acids (among them Ser 1700 and Thr 1704 in the carboxy-terminus of the Cav1.2 α1c subunit) has been implicated as decisive for the β-adrenergic …

Breast Cancer Tumor in a mouse, imaged with photoacoustics in 3D. Shows localization of a targeted nanoparticle (green) within the tumor. Left panel shows both photoacoustics and ultrasound images, overlaid. Right panel shows only the photoacoustics …

We have recently demonstrated that disruption of t; we serendipitously found that Cyp2c44 gene disrupt; the objective of the present study was to investig; which catalyzed the oxidation of arachidonic acid ; increases the numbers of 1) HSCs (CD34?; …

The strong relationship between cigarette smoking and cardiovascular disease (CVD) has been well-documented, but the mechanisms by which smoking increases CVD risk appear to be multifactorial and incompletely understood. Mesenchymal stem cells (MSCs) are …