Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after MI. Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages mice show better outcomes post-MI, while aged TG mice show a worse aging …

Comparative analyses of transcriptional profiles from humans and mice with cardiovascular pathologies revealed consistently ele- vated expression of MICU2, a regulatory subunit of the mitochon- drial calcium uniporter complex. To determine if MICU2 …

Intravenous bolus injection of non-targeted MicroMarker TM contrast agent in a mouse mammary tumor. The MIP(Maximum Intensity Persistence) setting can be adjusted to give a better visual representation of the vascular tree. … … Tumor …

Cancer was considered an incurable disease for many years; however, with the development of anticancer drugs and state-of-the art technologies, it has become curable. Cardiovascular diseases in patients with cancer or induced by cancer chemotherapy have …

Objectives—The purpose of this study was to evaluate vascular function, including arterial resistance and endothelial function, by high-resolution sonography in an Nx- nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced mouse model of …

Aims NADPH oxidase-4 (Nox4) is an important reactive oxygen species (ROS) source that is upregulated in the hemodynamically overloaded heart. Our previous studies using global Nox4 knockout (Nox4KO) mice demonstrated a protective role of Nox4 during …

Herein, we report the use of a theranostic nanocarrier (Folate-HBPE(CT20p)) to deliver a therapeutic peptide to prostate cancer tumors that express PSMA (folate hydrolase 1). The therapeutic peptide (CT20p) targets and inhibits the chaperonin-containing …

Background Sepsis is a leading cause of mortality among patients in intensive care units across the USA. Thioredoxin-1 (Trx-1) is an essential 12 kDa cytosolic protein that, apart from maintaining the cellular redox state, possesses multifunctional …

Cross section of the mouse abdomen with liver metastasis. … … Liver Metastasis …

Objective For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most …