Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is characterized by cardiac conduction abnormalities and left ventricular systolic dysfunction predisposing to heart failure. Previous cardiac …

Nanosized drug delivery systems have offered promising approaches for cancer theranostics. However, few are effective to simultaneously maximize tumor-specific uptake, imaging, and therapy in a single nanoplatform. Here, we report a simple yet …

Quercetin plays an important role in myocardial ischemia and reperfusion injury (IRI). However, the un- derlying mechanism for the protective effect of quercetin is largely unclear. In this study, we explored the protected effects of quercetin against …

Apical 4 chamber view of the mouse heart with color Doppler indicating flow through the mitral valve. … … Apical 4 Chamber view …

Triptolide is the predominant active component of the Chinese herb Tripterygium wilfordii Hook F (TwHF) that has been widely used to treat several chronic inflammatory diseases due to its immuno- suppressive, anti-inflammatory, and anti-proliferative …

Rationale: Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a- 3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, induce cardiac regeneration …

Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is characterized by cardiac conduction abnormalities and left ventricular systolic dysfunction predisposing to heart failure. Previous cardiac …

Aims Impaired Ca2þcycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects of adrenergic regulation of …

Heart failure is often the consequence of insufficient cardiac regeneration. Neonatal mice retain a certain capability of myocar- dial regeneration until postnatal day (P)7, although the underlying transcriptional mechanisms remain largely unknown. We …

PW Doppler of flow through the mitral valve from an apical 4 chamber view of the mouse heart with separation of E and A peaks visible. … … PW Doppler of Mitral …