OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …

Background: Prenatal alcohol exposure (PAE) can result in physical and neurocognitive deficits that are collectively termed “fetal alcohol spectrum disorders” (FASD). Although FASD is associated with lifelong intellectual disability, the mechanisms …

Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively …

Cardiac regenerative therapy has received attention as a potentially revolutionary approach for treating the damaged heart. The mouse model of myocardial infarction (MI) remains one of the most common tools for the evaluation of such new therapies. …

There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart,which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under …

Introduction: Types 1 and 2 diabetes have different causative mechanisms. Hence, different extent of cardiovascular, cognitive and auditory functions could be expected. Materials and methods: Body weight, blood glucose were measured in Wild type(WT), …

Assessment of right ventricular (RV) function in rodents is a challenge due to the complex RV anatomy and structure. Subsequently, the best characterization of RV function is achieved by accurate cardiovascular phenotyping, involving a combination of …

Uncontrolled activation of pro-inflammatory macrophages after myocardial infarction (MI) accelerates adverse left ventricular (LV) remodeling and dysfunction. Hemin, an iron-containing porphyrin, activates heme oxygen- ase-1 (HO-1), an enzymewith …

[[{"fid":"5808","view_mode":"default","fields":{},"type":"media","field_deltas":{"4":{}},"attributes":{"class":"media-element file-default","data-delta":"4"}}]] Small molecular dyes are used extensively for in vivo fluorescence imaging as well as in …

Cardiac fibrosis is a common finding in patients with chronic kidney disease. Here, we investigate the cardio-renal effects of theracurmin, a novel formulation of the polyphenolic compound curcumin, in a rat model of chronic kidney disease. Briefly, …