Small molecular dyes are used extensively for in vivo fluorescence imaging as well as in microscopy for identifying cellular and molecular processes. Since photoacoustic imaging with the Vevo LAZR system relies on optical absorption in the near-infrared (NIR) part of the spectrum, dyes with excitation peaks in this range can be used as contrast agents.
While higher doses are typically required than for optical imaging, photoacoustic imaging can overcome limitations of optical modalities such as autofluorescence, resolution at depth and accurate quantification.
Explore the possibilities of Angiostamp™800
NIR molecular imaging agent for oncology
AngiostampTM 800 is an organic near-infrared (NIR) fluorescent and photoacoustic imaging agent licensed by Optimal Grenoble, a small animal imaging team in France. It is a NIR imaging agent targeting the αvβ3 integrin. The αvβ3 integrin is overexpressed at the surface of activated endothelial cells during angiogenesis and in various types of tumor cells.
Initially developed as a contrast agent for tumor detection using fluorescence, AngiostampTM 800 can also be used for detecting tumors with high resolution at depth using photoacoustic imaging.
- Download the AngiostampTM 800 flyer from Optimal Grenoble
- Visit the Featured Publication highlighting the use of AngiostampTM 800 and high resolution photoacoustic imaging to stage liver metastasis in a mouse model