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Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway
Dipeptidyl peptidase 4 inhibitors are used worldwide in the management of diabetes, but their role in the prevention or treatment of cardiovascular disorders has yet to be defined. We found that linagliptin, a DPP-4 inhibitor, suppressed capillary …
Publication
A novel experimental model of erectile dysfunction in rats with heart failure using volume overload
Background: Patients with heart failure (HF) display erectile dysfunction (ED). However, the pathophysiology of ED during HF remains poorly investigated. Objective: This study aimed to characterize the aortocaval fistula (ACF) rat model associated with HF …
Publication
IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p
Immunoglobulin E (IgE) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. Our current study shows a novel mechanism involving IgE, FcɛR1, miRNA-212-5p (miR-212-5p), and …
Publication
Activation of transient receptor potential vanilloid 4 involves in hypoxia/reoxygenation injury in cardiomyocytes
Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly …
Publication
Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice
Aim: An increased density of intraplaque (IP) microvessels in ruptured versus nonruptured human plaques suggests that IP neovascularization has a major causative effect on plaque development and instability. Possibly, vascular endothelial growth factor …
Publication
Overexpression of microRNA-138 attenuates cardiac hypertrophic response through repression of YAP1
MicroRNAs (miRNAs) have been identified as important players in the pathogenesis of cardiac hypertrophy. In the present study, we evaluated the potential role of miR-138 in cardiac hypertrophy and the potential molecular mechanisms. We observed that in …
Publication
Photoacoustic imaging of lymphatic pumping
The lymphatic system is crucial for maintaining fluid balance in tissues and for immune cell trafficking; however, there are only a few methods for imaging lymphatic function in vivo. Lymph node biopsies are a common approach to diagnose illness; however, …
Publication
Detrimental role of lysyl oxidase in cardiac remodeling
A key feature of heart failure is adverse extracellular matrix (ECM) remodeling, which is associated with increases in the collagen cross-linking enzyme, lysyl oxidase (LOX). In this study, we assess the progression of cardiovascular remodeling from the …
Publication
A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model
This study was designed to investigate the effect of single-dose radiation therapy (RT) in combination with evofosfamide (TH-302), a hypoxia-activated prodrug, in a pre-clinical model of pancreatic cancer. AsPC1 tumors were implanted orthotopically in the …
Publication
Altered Penile Caveolin Expression in Diabetes: Potential Role in Erectile Dysfunction
Background The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric …