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Ultrasound image-guided cancer gene therapy using iRGD dual-targeted magnetic cationic microbubbles
The gene therapy attracted more and more attention for the tumor therapy. To obtain a safe gene therapy system, the new gene vectors beyond the virus were developed for a high gene therapy efficiency. The ultrasound mediated gene therapy was safer and the …
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Truncated PD1 Engineered Gas-Producing Extracellular Vesicles for Ultrasound Imaging and Subsequent Degradation of PDL1 in Tumor Cells
PDL1 blockade therapy holds great promise in cancer immunotherapy. Ultrasound imaging of PDL1 expression in the tumor is of great importance in predicting the therapeutic efficacy. As a proof-of-concept study, a novel ultrasound contrast agent has been …
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Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human
Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed …
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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with myocardial hypertrophy, fibrosis and ventricular dysfunction. …
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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance …
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Corked Microcapsules Enabling Controlled Ultrasound-Mediated Protein Delivery
Corked Microcapsules Enabling Controlled Ultrasound-Mediated Protein Delivery …
Publication
GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization
GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization …
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Computational Super-Resolution for Ultrasound Localization Microscopy through Solving an Inverse Problem
Ultrasound localization microscopy (ULM) represents a significant advancement over traditional ultra-sound (US) imaging, enabling super-resolution (SR) imaging of microvascular structures with unprecedented detail, by using microbubbles (MBs) as highly …
Publication
Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis
Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis …
Publication
Ultrasound Image Velocimetry for High Spatiotemporal Resolution Blood Flow Velocity Field Mapping in Mice
Objective: Abnormal hemodynamics is thought to play an essential role in the development of cardiovascular diseases. Mouse models are widely used for elucidating the underlying mechanisms; however, their small size and high heart rates make it difficult …