© 2018 John Wiley & Sons, Ltd. Whole-brain radiotherapy is the standard of care for patients with breast cancer with multiple brain metastases and, although this treatment has been essential in the management of existing brain tumors, there are many known …

© 2018 The Author(s). Background: Many studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wall …

Background: We analysed the haemodynamics of indocyanine green (ICG) in mouse organs and tumours and evaluated responses to anti-angiogenic agents in an allograft tumour mouse model by photoacoustic imaging. Methods: Thirty-six male mice (aged 10–14 …

Although chronic inflammation is a central feature of heart failure (HF), the immune cell profiles differ with different underlying causes. This suggests that for immunomodulatory therapy in HF to be successful, it needs to be tailored to the specific …

Arterial stiffness and wave reflection are important components of the ventricular afterload. Therefore, we aimed to assess the arterial wave characteristics and mechanical properties of the proximal pulmonary arteries (PAs) in the hypoxic pulmonary …

Inflammatory cells such as macrophages can play a pro-tumorigenic role in the tumor stroma. Tumor-associated macrophages (TAMs) generally display an M2 phenotype with tumor-promoting activity; however, the mechanisms regulating the TAM phenotype remain …

Live ultrasound (left) and photoacoustic (right) coronal section of a mouse brain during ligation of the right common carotid artery. The red, white and blue color represents a parametric map of oxygen saturation clearly showing the drop in sO 2 in the …

We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted overexpression of the dominant negative Wv mutant protein (dn-c-kit-Tg) respond to pressure overload with robust cardiomyocyte (CM) cell cycle entry. Here, we tested if …

Recent smooth muscle cell (SMC) lineage tracing studies have revealed SMCs undergo remarkable changes in phenotype during development of atherosclerosis. Of major interest, we demonstrated that KLF4 in SMC is detrimental for overall lesion pathogenesis in …

Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis. In this study, we prepared multifunctional microspheres from …