Background: In the setting of metastatic RCC (mRCC), pazopanib is approved as first line therapy. Unfortunately treatment may lead to cardiotoxicity such as hypertension, heart failure, and myocardial ischemia. Objective: Define the in vivo role of …

Color Doppler image of the right ovary in a mouse, imaged with color Doppler. … … Mouse Ovary …

Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent for its strong antioxidative activity. However, its roles and …

Myocardial infarction (MI) is a common cardiovascular disease with high mortality. The aim of the present study was to determine the biological role of miR-145 in MI rats and hypoxia-injured cardiomyocytes and to eluci- date the potential mechanism. MI …

Background: Lung and pulmonary vascular maldevelopment in congenital diaphragmatic hernia (CDH) results in significant morbidity and mortality. Retinoic acid (RA) and imatinib have been shown to improve pulmonary morphology following prenatal …

The objective of this study is to test the hypothesis that increased muscle mass has positive effects on cardiovascular function. Specifically, we tested the hypothesis that increases in lean body mass caused by deletion of myostatin improves cardiac …

Immune cells are equipped with a number of recep- tors that recognize sterile injury and pathogens. We find that host immune cells release ATP as an inflam- matory signal in response to allogeneic transplanta- tion. ATP then acts via a feedback mechanism …

Color Doppler image of the ovarian artery and vein in a mouse. … … Ovarian Artery and Vein in a Mouse …

MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 cluster regulates cardiomyocyte proliferation in the prenatal and postnatal …

BACKGROUND: Epidemiological studies suggest that increased ozone exposure during gestation may compromise fetal growth. In particular, the im- plantation stage of pregnancy is considered a key window of susceptibility for this outcome. OBJECTIVES: The …