Rendering of a 3D power Doppler image illustrating the vascularity in the mouse paw in a model of collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria. … … Vascularity in the Mouse …

Immunoglobulin E (IgE) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. Our current study shows a novel mechanism involving IgE, FcɛR1, miRNA-212-5p (miR-212-5p), and …

Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly …

Aim: An increased density of intraplaque (IP) microvessels in ruptured versus nonruptured human plaques suggests that IP neovascularization has a major causative effect on plaque development and instability. Possibly, vascular endothelial growth factor …

MicroRNAs (miRNAs) have been identified as important players in the pathogenesis of cardiac hypertrophy. In the present study, we evaluated the potential role of miR-138 in cardiac hypertrophy and the potential molecular mechanisms. We observed that in …

The lymphatic system is crucial for maintaining fluid balance in tissues and for immune cell trafficking; however, there are only a few methods for imaging lymphatic function in vivo. Lymph node biopsies are a common approach to diagnose illness; however, …

Rendering of a 3D power Doppler image of a swollen joint due to collagen-induced arthritis. Image courtesy of Dr. Mandl, University of Vienna, Austria. … … Arthritic …

A key feature of heart failure is adverse extracellular matrix (ECM) remodeling, which is associated with increases in the collagen cross-linking enzyme, lysyl oxidase (LOX). In this study, we assess the progression of cardiovascular remodeling from the …

This study was designed to investigate the effect of single-dose radiation therapy (RT) in combination with evofosfamide (TH-302), a hypoxia-activated prodrug, in a pre-clinical model of pancreatic cancer. AsPC1 tumors were implanted orthotopically in the …

Background The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric …