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The oncoprotein Mdm2 is a RING domain–containing E3 ubiquitin ligase that ubiquitinates G protein–coupled receptor kinase 2 (GRK2) and β-arrestin2, thereby regulating β-adrenergic receptor (βAR) signaling and endocytosis. Previous studies showed that …
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Image guided injection into the developing eye. … … Injection into the Developing Eye …
Publication
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After …
Publication
Objective To examine the role of miR-124a in LPS- induced septic cardiac insufficiency where underlying mechanism is unclear. Results Expression of miR-124a was decreased in myocardium of LPS-induced septic cardiac dysfunc- tion model. miR-124a antagomiR …
Publication
Aims Luma is a recently discovered, evolutionarily conserved protein expressed in mammalian heart that is associated with the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex. The LINC complex structurally integrates the nucleus and the cytoplasm, …
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Ventricular chamber growth and development during perinatal circulatory transition is critical for functional adaptation of the heart. However, the chamber-specific programs of neonatal heart growth are poorly understood. We used integrated systems …
Publication
The olm (Proteus anguinus) is a troglomorphic, neotenous amphibian with extraordinary life expectancy and unique adaptations that deserve further investigation. A low reproductive rate and habitat decline render it threatened by extinction. Establishing …
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Image guided injection into the fetal heart in a mouse. … … Injection into the Fetal Heart …
Publication
Biochemical and Biophysical Research Communications Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting …
Publication
The (pro)renin receptor [(P)RR] has been implicated as a renin/prorenin receptor, and plays a role in local renin angiotensin system activation. Our goal was to investigate whether a transgenic mouse that expresses rat tonin [TGM'(rTon)] can regulate …