Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF).Mutations in KCNE3 have been associated with AF, and Kcne32/2 mice exhibit hyperaldosteronism. In this study, we used recently developed Kcne32/2 mice to study …

Abstract Bolus injections of adenosine and the A2A adenosine receptor (AR) selective agonist (regadenoson) are used clinically as a substitute for a stress test in people who cannot exercise. Using isolated tissue preparations, our lab has shown that …

Aims: Cardiac angiogenesis is an important determinant of heart failure.We examined the hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular endothelial growth factor (VEGF) receptor-2 activation, is caus- ally involved …

The irreversible loss of cardiomyocytes due to oxidative stress is the main cause of heart dysfunction following ischemia/reperfu- sion (I/R) injury and ageing-induced cardiomyopathy. Here, we report that CUEDC2, a CUE domain-containing protein, plays a …

There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunc- tion. An important role for complement in these outcomes is now demonstrated. Addition of C5a to electrically paced CMs caused …

Photoacoustic imaging (PAI) is an emerging tool that bridges the traditional depth limits of ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the acoustic waves generated in response to the absorption of pulsed laser …

In humans, the increased cardiovascular demands of pregnancy are met by increases in cardiac output (CO), stroke volume (SV), plasma volume (PV), and cardiac and aortic inner dimensions and a concurrent decrease in arterial pressure that indicates a fall …

BACKGROUND: Non-invasive micro-ultrasound was evaluated as a method to quantify intrauterine growth phenotypes in mice. Improved methods are required to accelerate research using genetically-altered mice to investigate the interactive roles of genes and …

Vascular complication occurrence increases with the duration of diabetes. The present study compared the peripheral blood flow in superficial skin among subjects with a short or long history of diabetes as compared to a healthy control group. Thirty-two …

In human pregnancy, abnormal placental hemodynamics likely contribute to the etiology of early-onset preeclampsia and fetal intrauterine growth restriction. The mouse is increasingly being deployed to study normal and abnormal mammalian placental …