November 2020: Cardiac protection by the leptin-brain melanocortin system in heart failure

This is a recording of a LIVE webinar presented by Alexander da Silva, PhD, Research Scientist IV at the University of Mississippi Medical Center in Jackson, MS on November 19th, 2020.

Topics discussed in this webinar will be:

  • Leptin acts on the central nervous system (CNS) to improve cardiac function and slow/halt progression of heart failure induced by myocardial infarction
  • Leptin’s CNS-mediated cardiac protection in heart failure requires activation of the brain melanocortin system, and more specifically of melanocortin-4 receptors (MC4R)
  • The beneficial cardiac effects of the leptin-MC4R axis is accompanied by increased cardiomyocyte mitochondrial biogenesis and efficiency, substrate oxidation, and cardiomyocyte contractility
  • Q&A Session