This study by Adelsperger et al. uses Vevo ultrasound imaging to generate predictive models for the formation and growth of abdominal aortic aneurysms (AAA).
Article Summary:
- Clinically, it is important to know at what point AAA require surgical intervention
- Angiotensin II is a very common mouse model for the study of AAA, however development of aneurysms is inconsistent and variable
- There is a need to distinguish effects of treatment versus normal variability in aneurysm growth in the mouse
- Vessel diameter, flow, 3D geometry, assessment of branching vessels and circumferential strain were measured by Vevo ultrasound
- Measurements by ultrasound were highly correlated with histological findings
- Analysis of ultrasound measurements allowed for successful prediction of aneurysm growth trends over time
- Final size and length of aneurysm was successfully predicted
Conclusion:
Comprehensive ultrasound data can help differentiate between normal variability in aneurysm growth between animals and the significant benefits of a treatment of interest.
1. Adelsperger AR, Phillips EH, Ibriga HS, Craig BA, Green LA, Murphy MP, et al. Development and growth trends in angiotensin II-induced murine dissecting abdominal aortic aneurysms. Physiol Rep. 2018;6(8):1–17.