Benefits of Cardiac Function by Simspson Method vs B-Mode Parasternal Long Axis

This study by Heinen et al. compares cardiac functional data in a myocardial infarct model acquired by B-Mode in parasternal long axis (PSLAX) versus Simpson method, versus MRI.

Article Summary:

  • Sought to prove if Simpson method is significantly more sensitive at detecting changes in cardiac function
  • Used measurements by MRI as gold standard comparison
  • Parameters investigated included: ejection fraction (EF), end diastolic volume (EDV) and end systolic volume (ESV)
  • EF by Simpson method showed higher correlation with MRI
  • Significance demonstrated using an experimental model where the cardioprotective effect of treatment was only detected by Simpson method and MRI
  • Postulated that altered left ventricular geometry in the infarct model leads to the lowered sensitivity in functional measurement from B-Mode PSLAX
  • Suggests that the ideal method for detecting cardiac function would be in real-time 3D



Cardiac disease models that cause ventricular deformity necessitate more sensitive methods of detecting cardiac functional changes than 2D PSLAX.


1. Heinen A, Raupach A, Behmenburg F, Hölscher N, Flögel U, Kelm M, et al. Echocardiographic Analysis of Cardiac Function After Infarction in Mice : Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method. Ultrasound Med Biol [Internet]. 2018;1–12. Available from: