Treatment of hepatocellular carcinoma by multimodal in situ vaccination using cryoablation and a plant virus immunostimulant

Mansur A., Ghani, Amandip, Bangar, Yunpeng, Yang, Eunkyeong, Jung, Consuelo, Sauceda, Tyler, Mandt, Sourabh, Shukla, Nicholas J.G., Webster, Nicole F., Steinmetz, Isabel G., Newton

Journal of Vascular and Interventional Radiology |

To test the hypothesis that cryoablation combined with intratumoral immunomodulating nanoparticles from cowpea mosaic virus (CPMV) as an in situ vaccination approach induces systemic antitumoral immunity in a murine model of hepatocellular carcinoma (HCC).

https://linkinghub.elsevier.com/retrieve/pii/S1051044323002282