Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia

Fei, Sun, Guolun, Wang, Arun, Pradhan, Kui, Xu, Jose, Gomez-Arroyo, Yufang, Zhang, Gregory T., Kalin, Zicheng, Deng, Ronald J., Vagnozzi, Hua, He, Andrew W., Dunn, Yuhua, Wang, Allen J., York, Rashmi S., Hegde, Jason C., Woods, Tanya V., Kalin, Jeffery D., Molkentin, Vladimir V., Kalinichenko

Circulation |

Background: Pulmonary hypertension (PH) is a common complication in patients with Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the FOXF1 gene. While the loss of alveolar microvasculature causes PH in ACDMPV patients, it is unknown whether increasing neonatal lung angiogenesis could prevent PH and right ventricular (RV) hypertrophy.

https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A7609