Vascular Biology
Preclinical Ultrasound for Vascular Biology Research
Visualize and Quantify Vascular Function
Ultra-High Frequency (UHF) Vevo imaging systems allow for non-invasive, real-time evaluation of vascular function with resolution down to 30 microns.
With UHF imaging and software, you can:
- Quantify pulse wave velocity and vascular resistance
- Detect aneurysm and plaque formation with 3D reconstruction
- Analyze vessel wall characteristics (i.e. diameter, strain, velocity, stiffness, etc.)
- Quantify blood flow and perfusion
Perfect for Animal Models of:
- Atherosclerosis
- Aneurysm
- Arteriosclerosis
- Vascular Ischemia
Vascular Biology
Right Femoral Artery Bifurcation in a Mouse
Gallery
Abdominal Aorta Used In Strain Analysis
B-mode image of the abdominal aorta with vessel wall velocity vector arrows used in strain analysis.
M-Mode of a Mouse Carotid Artery
M-mode image of mouse left common carotid.
Measurements: wall thickness and vessel diameter in systole and diastole.
Splenic Vasculature in a Mouse
Murine Renal Vasculature in 3D
3D Spleen and Kidney Vasculature
3D Power Doppler rendering of a mouse spleen and kidney, highlighting splenic and renal vasculature.
Blood flow in tumor
3D rendered high-resolution ultrasound (greyscale) and color Doppler (orange and blue) image of a subcutaneous tumor showing blood flow.
Blood flow in tumor
Blood flow in tumor
3D rendered high-resolution ultrasound (greyscale) and color Doppler (orange and blue) image of a subcutaneous tumor showing blood flow.
Publications
TOP PAPER
A critical role for macrophages in neovessel formation and the development of stenosis in tissue-engineered vascular grafts
The FASEB Journal
, Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers
Cardiovascular Research
, Temporal Progression of Aortic Valve Pathogenesis in a Mouse Model of Osteogenesis Imperfecta
Journal of Cardiovascular Development and Disease
, Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
Translational Research
, Gut-derived metabolites mediating cognitive development in 5-year-old children: Early-life transplant in mice has lasting effects throughout adulthood
Brain, Behavior, and Immunity
, Based on network pharmacology, gastrodin attenuates hypertension-induced vascular smooth muscle cell proliferation and PI3K/AKT pathway activation
Scientific reports
, Detecting vascular changes in tumour xenografts using micro-ultrasound and micro-ct following treatment with VEGFR-2 blocking antibodies.
Ultrasound in medicine & biology
, Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis.
Molecular cancer therapeutics
, The Vascular Disrupting Agent STA-9584 Exhibits Potent Antitumor Activity by Selectively Targeting Microvasculature at Both the Center and Periphery of Tumors
Journal of Pharmacology and Experimental Therapeutics
, Resources
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