Faster skin wound healing predicts survival after myocardial infarction

Mediha, Becirovic-Agic, Upendra, Chalise, Mira, Jung, Jocelyn R., Rodriguez-Paar, Shelby R., Konfrst, Elizabeth R., Flynn, Jeffrey D., Salomon, Michael E., Hall, Merry L., Lindsey

American Journal of Physiology-Heart and Circulatory Physiology | 2022

Faster skin wound healers had more efficient cardiac healing after myocardial infarction (MI). Two plasma proteins at D3 MI, EAF1 and A2M, predicted MI death in 66% of cases. ApoD regulated both skin and cardiac wound healing in male mice by promoting inflammation. The skin was a mirror to the heart and common pathways linked wound healing across organs.

https://journals.physiology.org/doi/10.1152/ajpheart.00612.2021