Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure

Michael Thomas, Davidson, Paul, Grimsrud, Ling, Lai, James, Draper, Kelsey H, Fisher-Wellman, Tara Morgan, Narowski, Timothy R, Koves, Daniel P, Kelly, Deborah M, Muoio

Circulation Research |

Rationale: Circumstantial evidence links the development of heart failure to post-translational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse.

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.317293