Cardioprotective Effects of n-3 Polyunsaturated Fatty Acids: Orchestration of mRNA Expression, Protein Phosphorylation, and Lipid Metabolism in Pressure Overload Hearts

Xiang, Li, Weijiang, Tan, Shuang, Zheng, Junjie, Zhang, Caiyi, Zhu, Chun, Cai, Honghua, Chen, Chenqi, Yang, Le, Kang, Zhanhong, Pan, W. Glen, Pyle, Peter H., Backx, Yunzeng, Zou, Feng Hua, Yang

Frontiers in Cardiovascular Medicine |

Background: Pressure overload can result in dilated cardiomyopathy. The beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on heart disorders have been widely recognized. However, the molecular mechanisms underlying their protective effects against cardiomyopathy remain unclear.

https://www.frontiersin.org/articles/10.3389/fcvm.2021.788270/full