Acellular human amniotic fluid protects the ischemic-reperfused rat myocardium

Rather than targeting a single pathway implicated in myocardial reperfusion injury, cell-free human amniotic fluid—a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation—markedly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion. With its ubiquitous availability as well as its anti-inflammatory and nonimmunogenic properties, human cell-free amniotic fluid offers potential for use as a cardioprotective adjunct.